Through its contract with Pharmagenesis we have an exclusive license to five worldwide patent families
covering prodrugs and derivatives of triptolide. The extensive patent portfolio
includes the patents listed on Table 4.

|
Title
|
Filing Date
|
Application/Patent Number
|
Status
|
Lead Compound
|
|
Lactone Ring Derivatives |
3/2/04 |
US 7,863,464 |
Granted (US, CH), Pending (EU, JP) |
MRx102 |
|
Halogenated Triptolides |
2/23/04 |
US
6,943,259 |
Granted
(US,
EU, CH, JP) |
MRx103 |
|
C Ring Derivatives |
2/05/08 |
61/026,218 |
Pending (US, EU, CH, JP) |
MRx104 |
|
Esters |
03/01/96 |
US
5,962,516 |
Granted
(US, EU, CH, JP) |
MRx108 |
|
Carbonates |
05/31/02 |
US 7,662,976 |
Granted (US, JP) Pending (EU) |
MRx109 |